Cinnamic acids and derivatives

Ambeed Ethyl 4fluorobenzoate

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Ethyl 4-fluorobenzoate, 451-46-7, 98%

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Apexbio Technology LLC Entacapone 130929-57-6 10mM (in 1mL DMSO)

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Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect

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Medchemexpress LLC α-cyano-4-hydroxycinnamic acid | 28166-41-8 | MFCD00004204 | 99.9% | 189.17 | C10H7NO3 | 1 ML

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α-Cyano-4-hydroxycinnamic acid is a small-molecule inhibitor of monocarboxylate transporters commonly used in biochemical research and as a matrix in mass spectrometry. It is supplied at high purity and is available as both solid material and as a ready-to-use 10 mM solution in DMSO for laboratory use.

• High purity (99.9%) suitable for sensitive assays.
• Available as a 10 mM solution in DMSO for immediate use.
• Also available as solid in multiple sizes for flexible use.
• Effective monocarboxylate transporter inhibitor for in vitro studies.
• Suitable as a MALDI matrix for peptide analysis.
• Datasheet, certificate of analysis, and safety data sheet available.

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Medchemexpress LLC MEDCHEMEXPRESS LLC

5000453651 3 4 5-TRIMETHOXYCINN 50G

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Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 10 MG

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Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in research to block signaling pathways and reduce inflammatory responses, notably by inhibiting ICAM1 expression and TNFα-mediated cytotoxicity in vitro.

• Potent tyrosine kinase inhibitor.
• Inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
• Molecular formula C10H5N3O4; molecular weight 231.16 g/mol.
• Purity 98.7% as supplied.
• Soluble ≥125 mg/mL (≈540.75 mM) in DMSO.
• Appearance solid, light yellow to yellow.
• Recommended storage: powder -20°C up to 3 years or 4°C up to 2 years; in solution -80°C up to 6 months or -20°C up to 1 month.

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000390326 TRANS-CINNAMIC ACID- 25MG

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Medchemexpress LLC MEDCHEMEXPRESS LLC

5000438829 TYRPHOSTIN AG 112 25MG

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Apexbio Technology LLC Cinnamic acid 621-82-9 100mg

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Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection

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Chem-Impex International, Inc. Curcumin | 458-37-7 | MFCD00008365 | 25G

Curcumin, 458-37-7, MFCD00008365, 25G

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α-Fluorocinnamic Acid 98%, Thermo Scientific™

CAS: 350-90-3 Molecular Formula: C9H7FO2 Molecular Weight (g/mol): 166.151 InChI Key: QONCEXMULRJPPY-VURMDHGXSA-N Synonym: alpha-fluorocinnamic acid,.alpha.-fluorocinnamic acid,cinnamic acid, alpha-fluoro,z-alpha-fluorocinnamic acid,2-propenoic acid, 2-fluoro-3-phenyl,z-2-fluoro-3-phenylacrylic acid,2-fluoro-3-phenyl-2-propenoic acid,2z-2-fluoro-3-phenylprop-2-enoic acid,2-fluoro-3-phenylacrylic acid,cinnamic acid, .alpha.-fluoro PubChem CID: 1550911 IUPAC Name: (Z)-2-fluoro-3-phenylprop-2-enoic acid SMILES: C1=CC=C(C=C1)C=C(C(=O)O)F

Clocinnamox mesylate, Tocris Bioscience™

CAS: 117332-69-1 Molecular Formula: C30H33ClN2O7S Molecular Weight (g/mol): 601.111 InChI Key: XAXNKAGAUFXFDO-TYMYTQEGSA-N Synonym: clocinnamox mesylate,14?-p-chlorocinnamoylamino-7,8-dihydro-n-cyclopropylmethylmorphinone mesylate PubChem CID: 133655490 IUPAC Name: (E)-N-[(4S,4aR,7aS,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-chlorophenyl)prop-2-enamide;methanesulfonic acid SMILES: CS(=O)(=O)O.C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)NC(=O)C=CC7=CC=C(C=C7)Cl

A 350619 hydrochloride, Tocris Bioscience™

CAS: 1217201-17-6 Molecular Formula: C21H26Cl2N2OS Molecular Weight (g/mol): 425.412 InChI Key: PDVBHWZPRQFKJS-KYIGKLDSSA-N Synonym: a 350619 hydrochloride,3-2-4-chlorophenyl thiophenyl-n-4-dimethylamino butyl-2-propenamide hydrochloride,3-2-4-chlorophenyl thiophenyl-n-4-dimethylamino butyl-2-propenamidehcl PubChem CID: 56924282 IUPAC Name: (E)-3-[2-(4-chlorophenyl)sulfanylphenyl]-N-[4-(dimethylamino)butyl]prop-2-enamide;hydrochloride SMILES: CN(C)CCCCNC(=O)C=CC1=CC=CC=C1SC2=CC=C(C=C2)Cl.Cl

α-Cyano-βphenylacrylic Acid, MP Biomedicals

CAS: 1011-92-3 Molecular Formula: C10H7NO2 Molecular Weight (g/mol): 173.171 InChI Key: CDUQMGQIHYISOP-UHFFFAOYSA-N Synonym: 2-cyano-3-phenylacrylic acid,alpha-cyanocinnamicacid,cyanocinnamic acid,2-cyano-3-phenyl-2-propenoic acid,acmc-1b4v0,a-cyano-b-phenylacrylic acid,alpha-cyano-beta-phenyl-acrylic acid PubChem CID: 70534 IUPAC Name: 2-cyano-3-phenylprop-2-enoic acid SMILES: C1=CC=C(C=C1)C=C(C#N)C(=O)O

2-Chlorocinnamic acid, predominantly trans, 99%, Thermo Scientific™

CAS: 3752-25-8 Molecular Formula: C9H7ClO2 Molecular Weight (g/mol): 182.603 MDL Number: MFCD00004372 InChI Key: KJRRTHHNKJBVBO-AATRIKPKSA-N Synonym: 2-chlorocinnamic acid,o-chlorocinnamic acid,3-2-chlorophenyl acrylic acid,2e-3-2-chlorophenyl acrylic acid,e-3-2-chlorophenyl acrylic acid,cinnamic acid, o-chloro,2e-3-2-chlorophenyl prop-2-enoic acid,2-propenoic acid, 3-2-chlorophenyl,e-o-chlorocinnamic acid,3-2-chlorophenyl-2-propenoic acid PubChem CID: 700642 IUPAC Name: (E)-3-(2-chlorophenyl)prop-2-enoic acid SMILES: C1=CC=C(C(=C1)C=CC(=O)O)Cl

m-Hydroxycinnamic acid, 99%, predominantly trans, Thermo Scientific Chemicals

CAS: 14755-02-3 Molecular Formula: C₉H₈O₃ Molecular Weight (g/mol): 164.16 MDL Number: MFCD00004390 InChI Key: KKSDGJDHHZEWEP-SNAWJCMRSA-N Synonym: 3-hydroxycinnamic acid,3-coumaric acid,m-coumaric acid,m-hydroxycinnamic acid,3-3-hydroxyphenyl acrylic acid,e-3-3-hydroxyphenyl acrylic acid,trans-3-hydroxycinnamic acid,trans-3-hydroxycinnamate,cinnamic acid, m-hydroxy,2e-3-3-hydroxyphenyl prop-2-enoic acid PubChem CID: 637541 ChEBI: CHEBI:32357 IUPAC Name: (E)-3-(3-hydroxyphenyl)prop-2-enoic acid SMILES: C1=CC(=CC(=C1)O)C=CC(=O)O