Cinnamic acids and derivatives
Apexbio Technology LLC Ozagrel 82571-53-7 10mg
Ozagrel (CAS 82571-53-7) is a selective inhibitor of thromboxane A synthase an enzyme involved in the conversion of prostaglandin H to thromboxane A a potent mediator of platelet aggregation and vasoconstriction Ozagrel demonstrates high inhibitory potency with an IC of 4 nM indicating strong activity at low concentrations This compound is widely utilized in research to investigate thromboxane-dependent signaling pathways vascular biology and platelet function as well as in studies exploring potential therapeutic interventions targeting thrombotic and cardiovascular disorders
Selleck Chemical LLC Ferulic acid methyl ester S5451-25mg
Ferulic acid methyl ester (Methyl Ferulate Methyl 4 -hydroxy-3 -methoxycinnamate) is a lipophilic derivative of ferulic acid which is a hydroxycinnamic acid that is abundant in plants It shows the strongest antioxidant activity and can protect against inflammation and cancer
Medchemexpress LLC Cinnamic acid | 621-82-9 | MFCD00004369 | 148.16 | 1 G
Cinnamic acid has potential use in cancer intervention, exhibiting IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate, and lung carcinoma cells. In addition to inhibiting tumor-cell proliferation, Cinnamic acid induces morphological changes consistent with melanocyte differentiation. Treatment with Cinnamic acid also leads to a dose-dependent loss of invasive capacity in various tumor lines.
- Endogenous metabolite
- Potential use in cancer intervention
- Exhibits dose-dependent growth inhibition in various tumor cells
- Induces morphological changes consistent with melanocyte differentiation
- Causes dose-dependent loss of invasive capacity in tumor lines
- Purity: 99.98%
- Appearance: Solid
- Color: White to off-white
- Initial source: Microorganisms
- Storage: powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Tyrphostin AG1433 | 168835-90-3 | 99.1% | 1 ML
Tyrphostin AG1433 is a small-molecule tyrosine kinase inhibitor selective for PDGFRβ, supplied as a 10 mM solution in DMSO (1 mL) for research use. The compound has molecular formula C16H14N2O2 and molecular weight 266.29 g·mol⁻¹.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High purity (≈99.1%) suitable for biological research.
- Molecular formula C16H14N2O2; molecular weight 266.29 g·mol⁻¹.
- Also available as solid in multiple milligram quantities for custom preparations.
- For research use only; not for human or veterinary applications.
Medchemexpress LLC Cinnamic acid | 621-82-9 | MFCD00004369 | 148.16 | 500 MG
Cinnamic acid is a chemical compound with potential applications in cancer intervention. It has shown dose-dependent growth inhibition in various tumor cells, including glioblastoma, melanoma, prostate, and lung carcinoma cells, with IC50 values ranging from 1 to 4.5 mM.
- Potential use in cancer intervention.
- Exhibits dose-dependent growth inhibition in tumor cells.
- Induces morphological changes consistent with melanocyte differentiation.
- Causes a dose-dependent loss of invasive capacity in treated tumor lines.
- Effective in glioblastoma, melanoma, prostate, and lung carcinoma cells.
Medchemexpress LLC SAR405 R enantiomer | 1946010-79-2 | 99.9% | 443.85 | C19H21ClF3N5O2 | 10MG
SAR405 R enantiomer is the less active stereoisomer of the PIK3C3/Vps34 inhibitor SAR405, provided as a solid for in vitro research use only. It is suited for comparative pharmacology and control studies and includes handling and storage guidance for reliable experimental use.
- Less active enantiomer used as a comparative control in assays.
- High purity (≈99.9%).
- Solid, white to off-white appearance.
- Molecular formula C19H21ClF3N5O2; molecular weight 443.85.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store powder at -20°C for long-term stability; store solutions at -80°C.
- Intended for laboratory research use only.
Apexbio Technology LLC trans-Cinnamic acid 140-10-3 20mg
trans-Cinnamic acid (140-10-3) is a small-molecule inhibitor that exerts inhibitory activity against specific enzyme targets involved in inflammation oxidative stress and microbial proliferation It modulates these biological processes thereby regulating pathways associated with inflammatory response and antimicrobial defense trans-Cinnamic acid exerts its biological activity primarily through enzyme inhibition In in vitro studies trans-Cinnamic acid demonstrates inhibitory activity with reported IC50 values typically between 50 200 M depending on the experimental conditions and cell models Based on these pharmacological properties trans-Cinnamic acid holds research potential in anti-inflammatory antimicrobial antioxidant response studies and metabolic assays in tissue culture and cell-based experimental models
Medchemexpress LLC 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 99.96% | 238.24 | 1 ML
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of *Polygala tenuifolia WILLD*. It exhibits an anti-stress effect and prolongs sleeping time in animals. This compound increases the expression of GAD65 and the γ-subunit of the GABAA receptor, but does not affect the amounts of α- or β-subunits. It is for research use only.
- Anti-stress effect
- Prolongs sleeping time in animals
- Increases expression of GAD65 and γ-subunit of GABAA receptor
- For research use only
Cayman Chemical Plnt TurmerIc CurcumIn 5g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC p-Coumaric acid (standard) | 501-98-4 | 164.16 | 100 MG
p-Coumaric acid (Standard) is the analytical standard of p-Coumaric acid, intended for research and analytical applications. It is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation, promotes apoptosis, and exhibits antibacterial, anti-inflammatory, antioxidant, and anti-tumor activities.
- Analytical standard for research and analytical applications
- Inhibits cell proliferation and promotes apoptosis
- Exhibits antibacterial, anti-inflammatory, antioxidant, and anti-tumor activities
- Used as a reference standard in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Selleck Chemical LLC AMG-458 S2747-50mg
AMG 458 is a potent c-Met inhibitor with Ki of 1 2 nM 350-fold selectivity for c-Met than VEGFR2 in cells
Medchemexpress LLC cis-p-Coumaric acid | 4501-31-9 | 164.16 | 5 MG
cis-p-Coumaric acid, also known as cis-4-Hydroxycinnamic acid, is the cis-form of p-Coumaric acid. This compound is found in higher concentrations in viable groundnut seeds compared to non-viable ones.
- Exhibits oral activity.
- Inhibits cell proliferation.
- Promotes apoptosis.
Medchemexpress LLC p-Coumaric acid (trans-4-hydroxycinnamic acid) | 501-98-4 | 164.16 | 10 G
p-Coumaric acid, an isomer of cinnamic acid, demonstrates diverse biological activities including antibacterial, anti-inflammatory, antioxidant, and anti-tumor effects. It has been shown to inhibit cell proliferation and promote apoptosis, making it a subject of interest in various research applications.
- Inhibits proliferation of A375 and B16 cells.
- Promotes cell apoptosis in human and mouse melanoma cells.
- Exhibits antibacterial activity against gram-negative and gram-positive bacteria.
- Reduces polyp incidence and precancerous lesions in animal models.
- Alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress, inflammation, and apoptosis.
- Modulates cell cycle progression and protein expression in A375 and B16 cells.